Advanced Synthetic Methodologies

Explore breakthrough research articles, reaction mechanisms, and innovative strategies in organic synthesis.

Research Articles

Rewriting the Molecules of Life: The Era of Skeletal Editing

Discover how skeletal editing enables chemists to perform atomic-scale surgery on molecular frameworks, transforming medicine and materials science.

Skylar Hayes
Nov 03, 2025

Taming the Tiny Spring: How Chemists Master the Shape of Molecules

Discover how chemists are mastering molecular shape through systematic study of cyclopropyl ketones and their stereoselective reduction.

Logan Murphy
Nov 01, 2025

The Molecular Revolution: Building Blocks to Combat Age-Related Diseases

Explore the cutting-edge science of building specialized molecules to target the fundamental processes of aging and combat age-related diseases.

Aria West
Oct 28, 2025

Beyond the Mirror: How Stereochemistry Shapes Our World

Explore the fascinating world of stereochemistry - from medical tragedies to cutting-edge drugs, discover how molecular geometry transforms our lives.

Isaac Henderson
Oct 21, 2025

The Molecular Architect: Building Tomorrow, One Bond at a Time

Explore how synthetic organic chemistry shapes our world through medicine, materials, and molecular engineering

Kennedy Cole
Oct 12, 2025

The Impossible Molecules: How Chemists Built the First Topologically Non-Planar Hydrocarbons

Explore the fascinating world of centrohexacyclic molecules - the first topologically non-planar hydrocarbons that defy conventional chemical structures.

Noah Brooks
Oct 05, 2025

The Molecular Maze: Navigating the Impossible in Synthetic Chemistry

Explore the fascinating challenges of synthetic organic chemistry and how scientists build complex molecules like Taxol from scratch.

Sebastian Cole
Aug 23, 2025

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